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Year Number of Results
1997 1
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2005 2
2006 1
2007 2
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2009 6
2010 2
2011 8
2012 11
2013 12
2014 18
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2016 22
2017 14
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2024 8

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234 results

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Page 1
RUNX1/CEBPA Mutation in Acute Myeloid Leukemia Promotes Hypermethylation and Indicates for Demethylation Therapy.
Romanova EI, Zubritskiy AV, Lioznova AV, Ogunleye AJ, Golotin VA, Guts AA, Lennartsson A, Demidov ON, Medvedeva YA. Romanova EI, et al. Int J Mol Sci. 2022 Sep 27;23(19):11413. doi: 10.3390/ijms231911413. Int J Mol Sci. 2022. PMID: 36232714 Free PMC article.
RUNX1 and CEBPA can bind TET2 demethylase and attract it to their binding sites (TFBS) in cell lines, leading to DNA demethylation of the regions nearby. Since TET2 does not have a DNA-binding domain, TFs are crucial for its guidance to target genomic locations. In …
RUNX1 and CEBPA can bind TET2 demethylase and attract it to their binding sites (TFBS) in cell lines, leading to DNA demethyla …
The International Consensus Classification (ICC) of hematologic neoplasms with germline predisposition, pediatric myelodysplastic syndrome, and juvenile myelomonocytic leukemia.
Rudelius M, Weinberg OK, Niemeyer CM, Shimamura A, Calvo KR. Rudelius M, et al. Virchows Arch. 2023 Jan;482(1):113-130. doi: 10.1007/s00428-022-03447-9. Epub 2022 Nov 29. Virchows Arch. 2023. PMID: 36445482 Review.
Genes are organized into three major categories including (1) those that are not associated with constitutional disorder and include CEBPA, DDX41, and TP53; (2) those associated with thrombocytopenia or platelet dysfunction including RUNX1, ANKRD26, and ETV6; and (3 …
Genes are organized into three major categories including (1) those that are not associated with constitutional disorder and include CEBP …
Leukemia.
Chennamadhavuni A, Lyengar V, Mukkamalla SKR, Shimanovsky A. Chennamadhavuni A, et al. 2023 Jan 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Jan 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32809325 Free Books & Documents.
Many genetic risk factors have been identified, such as Klinefelter and Down syndromes, ataxia telangiectasia, Bloom syndrome, and telomeropathies such as Fanconi anemia, dyskeratosis congenita, and Shwachman-Diamond syndrome; germline mutations in RUNX1, CEBPA, to …
Many genetic risk factors have been identified, such as Klinefelter and Down syndromes, ataxia telangiectasia, Bloom syndrome, and telomerop …
A concise review on the molecular genetics of acute myeloid leukemia.
Padmakumar D, Chandraprabha VR, Gopinath P, Vimala Devi ART, Anitha GRJ, Sreelatha MM, Padmakumar A, Sreedharan H. Padmakumar D, et al. Leuk Res. 2021 Dec;111:106727. doi: 10.1016/j.leukres.2021.106727. Epub 2021 Oct 16. Leuk Res. 2021. PMID: 34700049 Review.
In this review we are discussing about the cytogenetics of AML and the recurrent gene alterations such us NPM1, FLT3, CEBPA, TET-2, c-KIT, DNMT3A, IDH, RUNX1, AXSL1, WT1, Ras gene mutations etc. ...
In this review we are discussing about the cytogenetics of AML and the recurrent gene alterations such us NPM1, FLT3, CEBPA, TET-2, c …
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group. Metzeler KH, et al. Blood. 2016 Aug 4;128(5):686-98. doi: 10.1182/blood-2016-01-693879. Epub 2016 Jun 10. Blood. 2016. PMID: 27288520 Free article. Clinical Trial.
In multivariate analyses including a comprehensive set of molecular and clinical variables, we identified DNMT3A and RUNX1 mutations as important predictors of shorter overall survival (OS) in AML patients <60 years, and particularly in those with intermediate-risk cyto …
In multivariate analyses including a comprehensive set of molecular and clinical variables, we identified DNMT3A and RUNX1 mutations …
Transcriptome-based molecular subtypes and differentiation hierarchies improve the classification framework of acute myeloid leukemia.
Cheng WY, Li JF, Zhu YM, Lin XJ, Wen LJ, Zhang F, Zhang YL, Zhao M, Fang H, Wang SY, Lin XJ, Qiao N, Yin W, Zhang JN, Dai YT, Jiang L, Sun XJ, Xu Y, Zhang TT, Chen SN, Zhu HH, Chen Z, Jin J, Wu DP, Shen Y, Chen SJ. Cheng WY, et al. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2211429119. doi: 10.1073/pnas.2211429119. Epub 2022 Nov 28. Proc Natl Acad Sci U S A. 2022. PMID: 36442087 Free PMC article.
Apart from four well-known low-risk subgroups including PML::RARA (G1), CBFB::MYH11 (G2), RUNX1::RUNX1T1 (G3), biallelic CEBPA mutations or -like (G4), four meta-subgroups with poor outcomes were recognized. ...
Apart from four well-known low-risk subgroups including PML::RARA (G1), CBFB::MYH11 (G2), RUNX1::RUNX1T1 (G3), biallelic CEBPA …
Germline predisposition in myeloid neoplasms: Unique genetic and clinical features of GATA2 deficiency and SAMD9/SAMD9L syndromes.
Sahoo SS, Kozyra EJ, Wlodarski MW. Sahoo SS, et al. Best Pract Res Clin Haematol. 2020 Sep;33(3):101197. doi: 10.1016/j.beha.2020.101197. Epub 2020 Jul 29. Best Pract Res Clin Haematol. 2020. PMID: 33038986 Free PMC article. Review.
The revised 2016 WHO classification introduced a novel category of "myeloid neoplasms with germline predisposition" with GATA2, CEBPA, DDX41, RUNX1, ANKRD26 and ETV6 genes expanding the spectrum of hereditary myeloid neoplasms (MN). ...
The revised 2016 WHO classification introduced a novel category of "myeloid neoplasms with germline predisposition" with GATA2, CEBPA …
AML classification in the year 2023: How to avoid a Babylonian confusion of languages.
Huber S, Baer C, Hutter S, Dicker F, Meggendorfer M, Pohlkamp C, Kern W, Haferlach T, Haferlach C, Hoermann G. Huber S, et al. Leukemia. 2023 Jul;37(7):1413-1420. doi: 10.1038/s41375-023-01909-w. Epub 2023 Apr 29. Leukemia. 2023. PMID: 37120689 Free PMC article.
Other genetically-defined AML remained the largest group, and the abandoned AML-RUNX1 was mainly reclassified as AML-MR (WHO 2022: 77%; ICC: 96%). Different inclusion criteria of AML-CEBPA and AML-MR (i.a. exclusion of TP53 mutated cases according to ICC) were assoc …
Other genetically-defined AML remained the largest group, and the abandoned AML-RUNX1 was mainly reclassified as AML-MR (WHO 2022: 77 …
Identification and interrogation of the gene regulatory network of CEBPA-double mutant acute myeloid leukemia.
Adamo A, Chin P, Keane P, Assi SA, Potluri S, Kellaway SG, Coleman D, Ames L, Ptasinska A, Delwel HR, Cockerill PN, Bonifer C. Adamo A, et al. Leukemia. 2023 Jan;37(1):102-112. doi: 10.1038/s41375-022-01744-5. Epub 2022 Nov 4. Leukemia. 2023. PMID: 36333583 Free PMC article.
In this study, we integrate gene expression, open chromatin and ChIP data with promoter-capture Hi-C data to define a refined core GRN common to all patients with CEBPA-double mutant (CEBPA(N/C)) AML. These mutations disrupt the structure of a major regulator of mye …
In this study, we integrate gene expression, open chromatin and ChIP data with promoter-capture Hi-C data to define a refined core GRN commo …
RUNX1-ETO Leukemia.
Lin S, Mulloy JC, Goyama S. Lin S, et al. Adv Exp Med Biol. 2017;962:151-173. doi: 10.1007/978-981-10-3233-2_11. Adv Exp Med Biol. 2017. PMID: 28299657 Review.
Genome-wide transcriptome and ChIP-seq analyses have revealed the genes directly regulated by AML1-ETO, such as CEBPA. Several lines of evidence suggest that AML1-ETO suppresses endogenous DNA repair in cells to promote mutagenesis, which facilitates acquisition of coopera …
Genome-wide transcriptome and ChIP-seq analyses have revealed the genes directly regulated by AML1-ETO, such as CEBPA. Several lines …
234 results